| Identification |
|---|
| HMDB Protein ID
| HMDBP13211 |
| Secondary Accession Numbers
| None |
| Name
| Glyceraldehyde-3-phosphate dehydrogenase |
| Synonyms
|
- GAPDH
- NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
|
| Gene Name
| GAP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.In vitro binds to human CD209 (DC-SIGN) and may help mediate adherence to host cells (PubMed:21203928). |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Carbon metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- Microbial metabolism in diverse environments
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| glucose metabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| NAD binding |
| NADP binding |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 339 |
| Molecular Weight
| 35955.52 |
| Theoretical pI
| 5.453 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A0H3MAB5 |
| UniProtKB/Swiss-Prot Entry Name
| G3P_MYCBP |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, Dos Santos S, Duthoy S, Lacroix C, Garcia-Pelayo C, Inwald JK, Golby P, Garcia JN, Hewinson RG, Behr MA, Quail MA, Churcher C, Barrell BG, Parkhill J, Cole ST: Genome plasticity of BCG and impact on vaccine efficacy. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5596-601. doi: 10.1073/pnas.0700869104. Epub 2007 Mar 19. [PubMed:17372194 ]
|
