| Identification |
|---|
| HMDB Protein ID
| HMDBP13196 |
| Secondary Accession Numbers
| None |
| Name
| Glyceraldehyde-3-phosphate dehydrogenase |
| Synonyms
|
- GAPDH
- NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
- Plasmin receptor
- Plasminogen-binding protein
|
| Gene Name
| GAP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Carbon metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- Microbial metabolism in diverse environments
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| glucose metabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| NAD binding |
| NADP binding |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 35972.525 |
| Theoretical pI
| 5.559 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DB18 |
| UniProtKB/Swiss-Prot Entry Name
| G3P_STRP3 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Beres SB, Sylva GL, Barbian KD, Lei B, Hoff JS, Mammarella ND, Liu MY, Smoot JC, Porcella SF, Parkins LD, Campbell DS, Smith TM, McCormick JK, Leung DY, Schlievert PM, Musser JM: Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10078-83. doi: 10.1073/pnas.152298499. Epub 2002 Jul 16. [PubMed:12122206 ]
|
