| Identification |
|---|
| HMDB Protein ID
| HMDBP13151 |
| Secondary Accession Numbers
| None |
| Name
| Enolase |
| Synonyms
|
- 2-phospho-D-glycerate hydro-lyase
- 2-phosphoglycerate dehydratase
|
| Gene Name
| ENO |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream. |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Carbon metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- Methane metabolism
- Microbial metabolism in diverse environments
- RNA degradation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| pathogenesis |
| Cellular Component |
| cytoplasm |
| cell surface |
| extracellular region |
| phosphopyruvate hydratase complex |
| cell wall |
| Molecular Function |
| magnesium ion binding |
| phosphopyruvate hydratase activity |
| zymogen binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 432 |
| Molecular Weight
| 46857.165 |
| Theoretical pI
| 4.779 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8DTS9 |
| UniProtKB/Swiss-Prot Entry Name
| ENO_STRMU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ: Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. doi: 10.1073/pnas.172501299. Epub 2002 Oct 23. [PubMed:12397186 ]
- Ge J, Catt DM, Gregory RL: Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen. Infect Immun. 2004 Nov;72(11):6748-52. doi: 10.1128/IAI.72.11.6748-6752.2004. [PubMed:15501816 ]
|
