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Showing Protein N-acetylglucosamine kinase 1 (HMDBP13110)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13110
Secondary Accession Numbers None
Name N-acetylglucosamine kinase 1
Synonyms
  1. GlcNAc kinase 1
  2. Hexokinase 1
Gene Name HXK1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the N-acetylglucosamine catabolic cascade that phosphorylates N-acetylglucosamine (GlcNAc), and allows the unique ability to utilise GlcNAc as carbon source. Converts GlcNAc to GlcNAc-6-P. Also able to phosphorylate glucose, glucosamine (GlcN), and mannose. Galactose, fructose, N-acetylmannosamine (ManNAc), mannosamine (ManN), galactosamine (GalN), and N-acetylgalactosamine (GalNAc) are not phosphorylated by HXK1. GlcNAc metabolism is closely associated with virulence and morphogenesis, and is involved in the cell wall synthesis. Acts both as a repressor and an activator of genes involved in maintaining cellular homeostasis. Contributes to white-opaque morphological transition and plays a role as a filamentation repressor.
Pathways
  • Amino sugar and nucleotide sugar metabolism
  • Biosynthesis of secondary metabolites
  • Carbon metabolism
  • Fructose and mannose metabolism
  • Galactose metabolism
  • glycolysis
  • Glycolysis / Gluconeogenesis
  • hexose metabolism
  • Starch and sucrose metabolism
Reactions Not Available
GO Classification
Biological Process
glycolysis
pathogenesis
glucose 6-phosphate metabolic process
hexose metabolic process
cellular glucose homeostasis
cell wall organization
Cellular Component
cytosol
mitochondrion
nucleus
Molecular Function
ATP binding
glucose binding
fructokinase activity
glucokinase activity
mannokinase activity
N-acetylglucosamine kinase activity
glucosamine kinase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 493
Molecular Weight 54822.32
Theoretical pI 5.395
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q59RW5
UniProtKB/Swiss-Prot Entry Name HXK1_CANAL
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Kumar MJ, Jamaluddin MS, Natarajan K, Kaur D, Datta A: The inducible N-acetylglucosamine catabolic pathway gene cluster in Candida albicans: discrete N-acetylglucosamine-inducible factors interact at the promoter of NAG1. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14218-23. doi: 10.1073/pnas.250452997. [PubMed:11114181 ]
  5. Yamada-Okabe T, Sakamori Y, Mio T, Yamada-Okabe H: Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans. Eur J Biochem. 2001 Apr;268(8):2498-505. doi: 10.1046/j.1432-1327.2001.02135.x. [PubMed:11298769 ]
  6. Singh P, Ghosh S, Datta A: Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway. Infect Immun. 2001 Dec;69(12):7898-903. doi: 10.1128/IAI.69.12.7898-7903.2001. [PubMed:11705974 ]
  7. Wendland J, Hellwig D, Walther A, Sickinger S, Shadkchan Y, Martin R, Bauer J, Osherov N, Tretiakov A, Saluz HP: Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. J Basic Microbiol. 2006;46(6):513-23. doi: 10.1002/jobm.200610167. [PubMed:17139615 ]
  8. Wendland J, Schaub Y, Walther A: N-acetylglucosamine utilization by Saccharomyces cerevisiae based on expression of Candida albicans NAG genes. Appl Environ Microbiol. 2009 Sep;75(18):5840-5. doi: 10.1128/AEM.00053-09. Epub 2009 Jul 31. [PubMed:19648376 ]
  9. Gunasekera A, Alvarez FJ, Douglas LM, Wang HX, Rosebrock AP, Konopka JB: Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z. Eukaryot Cell. 2010 Oct;9(10):1476-83. doi: 10.1128/EC.00178-10. Epub 2010 Jul 30. [PubMed:20675577 ]
  10. Naseem S, Gunasekera A, Araya E, Konopka JB: N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and transcriptional responses in Candida albicans are not dependent on its metabolism. J Biol Chem. 2011 Aug 19;286(33):28671-28680. doi: 10.1074/jbc.M111.249854. Epub 2011 Jun 23. [PubMed:21700702 ]
  11. Rao KH, Ghosh S, Natarajan K, Datta A: N-acetylglucosamine kinase, HXK1 is involved in morphogenetic transition and metabolic gene expression in Candida albicans. PLoS One. 2013;8(1):e53638. doi: 10.1371/journal.pone.0053638. Epub 2013 Jan 14. [PubMed:23341961 ]
  12. Rao KH, Ruhela D, Ghosh S, Abdin MZ, Datta A: N-acetylglucosamine kinase, HXK1 contributes to white-opaque morphological transition in Candida albicans. Biochem Biophys Res Commun. 2014 Feb 28;445(1):138-44. doi: 10.1016/j.bbrc.2014.01.123. Epub 2014 Jan 31. [PubMed:24491547 ]