| Identification |
|---|
| HMDB Protein ID
| HMDBP13102 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-enolase |
| Synonyms
|
- 2-phospho-D-glycerate hydro-lyase
- Enolase 1
- HAP47
- Non-neural enolase
- Phosphopyruvate hydratase
- NNE
|
| Gene Name
| ENO1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:7499243). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). |
| Pathways
|
- Biosynthesis of amino acids
- Carbon metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- HIF-1 signaling pathway
- RNA degradation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| canonical glycolysis |
| regulation of vacuole fusion, non-autophagic |
| Cellular Component |
| cytoplasm |
| plasma membrane |
| phosphopyruvate hydratase complex |
| Molecular Function |
| magnesium ion binding |
| phosphopyruvate hydratase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 434 |
| Molecular Weight
| 47325.715 |
| Theoretical pI
| 6.805 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9XSJ4 |
| UniProtKB/Swiss-Prot Entry Name
| ENOA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Aaronson RM, Graven KK, Tucci M, McDonald RJ, Farber HW: Non-neuronal enolase is an endothelial hypoxic stress protein. J Biol Chem. 1995 Nov 17;270(46):27752-7. doi: 10.1074/jbc.270.46.27752. [PubMed:7499243 ]
|
