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Showing Protein Transketolase (HMDBP13083)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13083
Secondary Accession Numbers None
Name Transketolase
Synonyms
  1. TK
Gene Name TKT
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Pathways
  • Biosynthesis of amino acids
  • Biosynthesis of secondary metabolites
  • Carbon metabolism
  • Microbial metabolism in diverse environments
  • Pentose phosphate pathway
Reactions Not Available
GO Classification
Biological Process
pentose-phosphate shunt
Cellular Component
cytosol
plasma membrane
extracellular region
cell wall
Molecular Function
metal ion binding
transketolase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 700
Molecular Weight 75588.025
Theoretical pI 5.152
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P9WG25
UniProtKB/Swiss-Prot Entry Name TKT_MYCTU
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159. [PubMed:9634230 ]
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [PubMed:21969609 ]
  3. Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST: Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme. Open Biol. 2012 Jan;2(1):110026. doi: 10.1098/rsob.110026. [PubMed:22645655 ]