| Identification |
|---|
| HMDB Protein ID
| HMDBP13066 |
| Secondary Accession Numbers
| None |
| Name
| Triosephosphate isomerase |
| Synonyms
|
- TIM
- Methylglyoxal synthase
- Triose-phosphate isomerase
|
| Gene Name
| TPI1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. |
| Pathways
|
- Biosynthesis of amino acids
- Carbon metabolism
- Fructose and mannose metabolism
- gluconeogenesis
- glycolysis
- Glycolysis / Gluconeogenesis
- Inositol phosphate metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| gluconeogenesis |
| glycolysis |
| methylglyoxal biosynthetic process |
| glycerol catabolic process |
| glyceraldehyde-3-phosphate biosynthetic process |
| Cellular Component |
| cytosol |
| Molecular Function |
| protein homodimerization activity |
| triose-phosphate isomerase activity |
| methylglyoxal synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 249 |
| Molecular Weight
| 26669.33 |
| Theoretical pI
| 6.906 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P60175 |
| UniProtKB/Swiss-Prot Entry Name
| TPIS_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Craig LC, Pirtle IL, Gracy RW, Pirtle RM: Characterization of the transcription unit and two processed pseudogenes of chimpanzee triosephosphate isomerase (TPI). Gene. 1991 Mar 15;99(2):217-27. doi: 10.1016/0378-1119(91)90130-4. [PubMed:2022334 ]
- Sakate R, Suto Y, Imanishi T, Tanoue T, Hida M, Hayasaka I, Kusuda J, Gojobori T, Hashimoto K, Hirai M: Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome. Gene. 2007 Sep 1;399(1):1-10. doi: 10.1016/j.gene.2007.04.013. Epub 2007 Apr 20. [PubMed:17574350 ]
|
