| Identification |
|---|
| HMDB Protein ID
| HMDBP13063 |
| Secondary Accession Numbers
| None |
| Name
| Triosephosphate isomerase |
| Synonyms
|
- TIM
- Allergen Scy p 8
- Methylglyoxal synthase
- Triose-phosphate isomerase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. |
| Pathways
|
- gluconeogenesis
- glycolysis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| gluconeogenesis |
| glycolysis |
| methylglyoxal biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| protein homodimerization activity |
| triose-phosphate isomerase activity |
| IgE binding |
| methylglyoxal synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 26973.725 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A1L5YRA2 |
| UniProtKB/Swiss-Prot Entry Name
| TPIS_SCYPA |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Yang Y, Hu MJ, Jin TC, Zhang YX, Liu GY, Li YB, Zhang ML, Cao MJ, Su WJ, Liu GM: A comprehensive analysis of the allergenicity and IgE epitopes of myosinogen allergens in Scylla paramamosain. Clin Exp Allergy. 2019 Jan;49(1):108-119. doi: 10.1111/cea.13266. Epub 2018 Oct 7. [PubMed:30187588 ]
- Xia F, Li MS, Liu QM, Liu M, Yang Y, Cao MJ, Chen GX, Jin T, Liu GM: Crystal Structure Analysis and Conformational Epitope Mutation of Triosephosphate Isomerase, a Mud Crab Allergen. J Agric Food Chem. 2019 Nov 20;67(46):12918-12926. doi: 10.1021/acs.jafc.9b05279. Epub 2019 Nov 11. [PubMed:31668066 ]
|
