| Identification |
|---|
| HMDB Protein ID
| HMDBP13007 |
| Secondary Accession Numbers
| None |
| Name
| Antifungal lectin AMML |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Lectin that binds strongly to galactose, lactose, D-raffinose, L-rhamnose and cellobiose, and less strongly to D-glucose, D-xylose and L-arabinose. Does not bind D-galacturonic acid, D-fructose, D-mannose, D-ribose, L-sorbose, maltose and sucrose. Has hemagglutinating activity towards human type O and rabbit erythrocytes. Has strong antifungal activity against B.cinera with an IC(50) value of 1.2 uM, and weaker antifungal activity against D.turcia, F.oxysporum and Colletorichum sp. Lacks antifungal activity against F.oxysporum and M.arachidicola. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| defense response to fungus |
| killing of cells of other organism |
| Molecular Function |
| glucose binding |
| galactose binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 1516.57 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P85004 |
| UniProtKB/Swiss-Prot Entry Name
| AMML_ASTMO |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Yan Q, Jiang Z, Yang S, Deng W, Han L: A novel homodimeric lectin from Astragalus mongholicus with antifungal activity. Arch Biochem Biophys. 2005 Oct 1;442(1):72-81. doi: 10.1016/j.abb.2005.07.019. [PubMed:16140255 ]
|
