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Showing Protein Phosphoserine aminotransferase (HMDBP12845)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12845
Secondary Accession Numbers None
Name Phosphoserine aminotransferase
Synonyms
  1. Phosphohydroxythreonine aminotransferase
  2. PSAT
Gene Name SERC
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis.
Pathways
  • Biosynthesis of amino acids
  • Biosynthesis of cofactors
  • Biosynthesis of secondary metabolites
  • Carbon metabolism
  • Cysteine and methionine metabolism
  • Glycine, serine and threonine metabolism
  • L-serine biosynthesis
  • Methane metabolism
  • Microbial metabolism in diverse environments
  • pyridoxine 5'-phosphate biosynthesis
  • Vitamin B6 metabolism
Reactions Not Available
GO Classification
Biological Process
L-serine biosynthetic process
pyridoxal phosphate biosynthetic process
pyridoxine biosynthetic process
L-serine metabolic process
lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate
Cellular Component
cytosol
cytoplasm
Molecular Function
pyridoxal phosphate binding
O-phospho-L-serine:2-oxoglutarate aminotransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 362
Molecular Weight 39782.955
Theoretical pI 5.591
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P23721
UniProtKB/Swiss-Prot Entry Name SERC_ECOLI
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [PubMed:9278503 ]
  2. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [PubMed:16738553 ]
  3. Link AJ, Robison K, Church GM: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis. 1997 Aug;18(8):1259-313. [PubMed:9298646 ]
  4. Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. [PubMed:8905232 ]
  5. Hester G, Stark W, Moser M, Kallen J, Markovic-Housley Z, Jansonius JN: Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. J Mol Biol. 1999 Feb 26;286(3):829-50. [PubMed:10024454 ]
  6. Duncan K, Coggins JR: The serC-aro A operon of Escherichia coli. A mixed function operon encoding enzymes from two different amino acid biosynthetic pathways. Biochem J. 1986 Feb 15;234(1):49-57. doi: 10.1042/bj2340049. [PubMed:3518706 ]
  7. van der Zel A, Lam HM, Winkler ME: Extensive homology between the Escherichia coli K-12 SerC(PdxF) aminotransferase and a protein encoded by a progesterone-induced mRNA in rabbit and human endometria. Nucleic Acids Res. 1989 Oct 25;17(20):8379. doi: 10.1093/nar/17.20.8379. [PubMed:2682527 ]
  8. Lam HM, Winkler ME: Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. J Bacteriol. 1990 Nov;172(11):6518-28. doi: 10.1128/jb.172.11.6518-6528.1990. [PubMed:2121717 ]
  9. Drewke C, Klein M, Clade D, Arenz A, Muller R, Leistner E: 4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis. FEBS Lett. 1996 Jul 22;390(2):179-82. doi: 10.1016/0014-5793(96)00652-7. [PubMed:8706854 ]