Hmdb loader
Identification
HMDB Protein ID HMDBP12794
Secondary Accession Numbers None
Name Transcription elongation factor A protein-like 7
Synonyms
  1. TCEA-like protein 7
  2. Transcription elongation factor S-II protein-like 7
Gene Name TCEAL7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of NF-kappaB transcription factor activity
negative regulation of transcription, DNA-dependent
Cellular Component
nucleus
nucleoplasm
Molecular Function
WW domain binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 100
Molecular Weight 12323.775
Theoretical pI 8.294
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BRU2
UniProtKB/Swiss-Prot Entry Name TCAL7_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  5. Lafferty-Whyte K, Bilsland A, Hoare SF, Burns S, Zaffaroni N, Cairney CJ, Keith WN: TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. Neoplasia. 2010 May;12(5):405-14. doi: 10.1593/neo.10180. [PubMed:20454512 ]
  6. Rattan R, Narita K, Chien J, Maguire JL, Shridhar R, Giri S, Shridhar V: TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway. Oncogene. 2010 Mar 4;29(9):1362-73. doi: 10.1038/onc.2009.431. Epub 2009 Dec 7. [PubMed:19966855 ]