| Identification |
|---|
| HMDB Protein ID
| HMDBP12785 |
| Secondary Accession Numbers
| None |
| Name
| Small t antigen |
| Synonyms
|
- ST
- ST-AG
|
| Gene Name
| (REFSEQ) JC POLYOMAVIRUS; HYPOTHETICAL PROTEIN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral reproduction |
| Cellular Component |
| host cell nucleus |
| host cell cytoplasm |
| Molecular Function |
| metal ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 20237.355 |
| Theoretical pI
| 7.747 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P03083 |
| UniProtKB/Swiss-Prot Entry Name
| ST_POVJC |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Frisque RJ, Bream GL, Cannella MT: Human polyomavirus JC virus genome. J Virol. 1984 Aug;51(2):458-69. doi: 10.1128/JVI.51.2.458-469.1984. [PubMed:6086957 ]
- Frisque RJ: Regulatory sequences and virus-cell interactions of JC virus. Prog Clin Biol Res. 1983;105:41-59. [PubMed:6304771 ]
|
