| Identification |
|---|
| HMDB Protein ID
| HMDBP12775 |
| Secondary Accession Numbers
| None |
| Name
| Small t antigen |
| Synonyms
|
- ST
- ST-AG
|
| Gene Name
| (REFSEQ) HUMAN POLYOMAVIRUS 1; SMALL T ANTIGEN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral reproduction |
| Cellular Component |
| host cell nucleus |
| host cell cytoplasm |
| Molecular Function |
| metal ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 20454.775 |
| Theoretical pI
| 7.205 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P03082 |
| UniProtKB/Swiss-Prot Entry Name
| ST_POVBK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Seif I, Khoury G, Dhar R: The genome of human papovavirus BKV. Cell. 1979 Dec;18(4):963-77. doi: 10.1016/0092-8674(79)90209-5. [PubMed:229976 ]
- Yang RC, Wu R: BK virus DNA: complete nucleotide sequence of a human tumor virus. Science. 1979 Oct 26;206(4417):456-62. doi: 10.1126/science.228391. [PubMed:228391 ]
- Yang RC, Young A, Wu R: BK virus DNA sequence coding for the t and T antigens and evaluation of methods for determining sequence homology. J Virol. 1980 May;34(2):416-30. doi: 10.1128/JVI.34.2.416-430.1980. [PubMed:6246273 ]
- Yang RC, Wu R: Comparative study of papovavirus DNA: BKV(MM), BKV(WT) and SV40. Nucleic Acids Res. 1979 Oct 10;7(3):651-68. doi: 10.1093/nar/7.3.651. [PubMed:228246 ]
|
