Hmdb loader
Identification
HMDB Protein ID HMDBP12768
Secondary Accession Numbers None
Name Methyl-CpG-binding domain protein 1
Synonyms
  1. Methyl-CpG-binding protein MBD1
Gene Name MBD1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of gene expression
negative regulation of astrocyte differentiation
Cellular Component
cytoplasm
nucleus
nuclear matrix
chromatin
nuclear speck
heterochromatin
Molecular Function
zinc ion binding
chromatin binding
DNA binding
unmethylated CpG binding
methyl-CpG binding
double-stranded methylated DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 636
Molecular Weight 70022.035
Theoretical pI 8.66
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Z2E2
UniProtKB/Swiss-Prot Entry Name MBD1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Hendrich B, Bird A: Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47. [PubMed:9774669 ]
  4. Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A: Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Mamm Genome. 1999 Sep;10(9):906-12. [PubMed:10441743 ]
  5. Reese BE, Bachman KE, Baylin SB, Rountree MR: The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. Mol Cell Biol. 2003 May;23(9):3226-36. [PubMed:12697822 ]
  6. Jorgensen HF, Ben-Porath I, Bird AP: Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol. 2004 Apr;24(8):3387-95. doi: 10.1128/MCB.24.8.3387-3395.2004. [PubMed:15060159 ]
  7. Nunes SM, Ferralli J, Choi K, Brown-Luedi M, Minet AD, Chiquet-Ehrismann R: The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. Exp Cell Res. 2005 Apr 15;305(1):122-32. doi: 10.1016/j.yexcr.2004.12.020. [PubMed:15777793 ]