Hmdb loader
Identification
HMDB Protein ID HMDBP12758
Secondary Accession Numbers None
Name Corticoliberin
Synonyms
  1. Corticotropin-releasing factor
  2. Corticotropin-releasing hormone
  3. CRF
Gene Name CRH
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Pathways
  • Alcoholism
  • cAMP signaling pathway
  • Cushing syndrome
  • Long-term depression
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of circadian sleep/wake cycle, REM sleep
parturition
negative regulation of norepinephrine secretion
associative learning
long-term synaptic potentiation
diterpenoid metabolic process
response to ether
synaptic transmission, dopaminergic
positive regulation of calcium ion import
positive regulation of corticotropin secretion
cellular response to cocaine
hormone-mediated apoptotic signaling pathway
ion homeostasis
negative regulation of cell death
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of glucagon secretion
negative regulation of luteinizing hormone secretion
negative regulation of systemic arterial blood pressure
positive regulation of behavioral fear response
positive regulation of cAMP-mediated signaling
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of corticosterone secretion
positive regulation of cortisol secretion
positive regulation of digestive system process
regulation of NMDA receptor activity
regulation of serotonin secretion
response to immobilization stress
signal transduction
response to drug
response to ethanol
positive regulation of cell death
positive regulation of cell proliferation
synaptic transmission
learning or memory
inflammatory response
steroid metabolic process
positive regulation of gene expression
response to corticosterone stimulus
cellular response to dexamethasone stimulus
response to estrogen stimulus
negative regulation of gene expression
negative regulation of epinephrine secretion
negative regulation of inflammatory response to antigenic stimulus
female pregnancy
response to pain
positive regulation of protein phosphorylation
hypothalamus development
G-protein coupled receptor signaling pathway
Cellular Component
extracellular space
synapse
cytoplasm
perikaryon
varicosity
extracellular region
Molecular Function
receptor binding
corticotropin-releasing hormone receptor 1 binding
hormone activity
neuropeptide hormone activity
corticotropin-releasing hormone activity
corticotropin-releasing hormone receptor 2 binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 196
Molecular Weight 21421.505
Theoretical pI 9.96
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P06850
UniProtKB/Swiss-Prot Entry Name CRF_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [PubMed:16303743 ]
  3. Shibahara S, Morimoto Y, Furutani Y, Notake M, Takahashi H, Shimizu S, Horikawa S, Numa S: Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J. 1983;2(5):775-9. [PubMed:6605851 ]
  4. Robinson BG, D'Angio LA Jr, Pasieka KB, Majzoub JA: Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. Mol Cell Endocrinol. 1989 Feb;61(2):175-80. [PubMed:2783917 ]
  5. Sasaki A, Tempst P, Liotta AS, Margioris AN, Hood LE, Kent SB, Sato S, Shinkawa O, Yoshinaga K, Krieger DT: Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. J Clin Endocrinol Metab. 1988 Oct;67(4):768-73. [PubMed:3262120 ]
  6. Romier C, Bernassau JM, Cambillau C, Darbon H: Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. Protein Eng. 1993 Feb;6(2):149-56. [PubMed:8386360 ]
  7. Pioszak AA, Parker NR, Suino-Powell K, Xu HE: Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008 Nov 21;283(47):32900-12. doi: 10.1074/jbc.M805749200. Epub 2008 Sep 17. [PubMed:18801728 ]
  8. Sansoni V, Forcella M, Mozzi A, Fusi P, Ambrosini R, Ferini-Strambi L, Combi R: Functional characterization of a CRH missense mutation identified in an ADNFLE family. PLoS One. 2013 Apr 11;8(4):e61306. doi: 10.1371/journal.pone.0061306. Print 2013. [PubMed:23593457 ]