| Identification |
|---|
| HMDB Protein ID
| HMDBP12755 |
| Secondary Accession Numbers
| None |
| Name
| Corticostatin-4 |
| Synonyms
|
- Antiadrenocorticotropin peptide IV
- Corticostatin IV
- Macrophage antibiotic peptide MCP-2
- CS-IV
- NP-2
|
| Gene Name
| (REFSEQ) MACROPHAGE CATIONIC PEPTIDE 2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production. |
| Pathways
|
- NOD-like receptor signaling pathway
- Staphylococcus aureus infection
- Transcriptional misregulation in cancer
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| defense response to virus |
| defense response to bacterium |
| defense response to fungus |
| killing of cells of other organism |
| Cellular Component |
| extracellular space |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 95 |
| Molecular Weight
| 10431.1 |
| Theoretical pI
| 7.705 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P01377 |
| UniProtKB/Swiss-Prot Entry Name
| DEF4_RABIT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F: The structure of the rabbit macrophage defensin genes and their organ-specific expression. J Immunol. 1989 Aug 15;143(4):1358-65. [PubMed:2745983 ]
- Sadro LC, Tremblay A, Solomon S, Palfree RG: Differential expression of corticostatins/defensins: higher levels of CS-4 (NP-2) transcripts compared with CS-6 (NP-5) in rabbit lung. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1009-16. doi: 10.1006/bbrc.1993.1149. [PubMed:8439302 ]
- Selsted ME, Brown DM, DeLange RJ, Lehrer RI: Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem. 1983 Dec 10;258(23):14485-9. [PubMed:6643497 ]
- Zhu Q, Solomon S: Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. Endocrinology. 1992 Mar;130(3):1413-23. doi: 10.1210/endo.130.3.1311240. [PubMed:1311240 ]
- Zhang XL, Selsted ME, Pardi A: NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry. 1992 Nov 24;31(46):11348-56. doi: 10.1021/bi00161a012. [PubMed:1445872 ]
- Pardi A, Zhang XL, Selsted ME, Skalicky JJ, Yip PF: NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. Biochemistry. 1992 Nov 24;31(46):11357-64. doi: 10.1021/bi00161a013. [PubMed:1445873 ]
|
