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Showing Protein GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (HMDBP12752)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12752
Secondary Accession Numbers None
Name GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Synonyms
  1. Alpha-1,2-mannosyltransferase ALG11
  2. Asparagine-linked glycosylation protein 11
  3. Glycolipid 2-alpha-mannosyltransferase
Gene Name ALG11
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.
Pathways
  • N-Glycan biosynthesis
  • protein glycosylation
  • Various types of N-glycan biosynthesis
Reactions Not Available
GO Classification
Biological Process
protein glycosylation
protein N-linked glycosylation
oligosaccharide-lipid intermediate biosynthetic process
Cellular Component
integral to membrane
endoplasmic reticulum membrane
membrane
Molecular Function
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
alpha-1,2-mannosyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 548
Molecular Weight 63142.705
Theoretical pI 8.988
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 21-41;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P53954
UniProtKB/Swiss-Prot Entry Name ALG11_YEAST
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N: The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. J Biol Chem. 2001 Jun 15;276(24):21828-40. doi: 10.1074/jbc.M010896200. Epub 2001 Feb 15. [PubMed:11278778 ]
  2. Bergez P, Doignon F, Crouzet M: The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae. Yeast. 1995 Aug;11(10):967-74. doi: 10.1002/yea.320111008. [PubMed:8533472 ]
  3. Bergez P, Doignon F, Crouzet M: Corrigendum to: the sequence of a 44 458 bp fragment located on the left arm of chromosome XIV from Saccharomyces cervisiae. Yeast. 1996 Mar 15;12(3):297. doi: 10.1002/(sici)1097-0061(19960315)12:3<297::aid-yea940>3.0.co;2-d. [PubMed:8904343 ]
  4. Philippsen P, Kleine K, Pohlmann R, Dusterhoft A, Hamberg K, Hegemann JH, Obermaier B, Urrestarazu LA, Aert R, Albermann K, Altmann R, Andre B, Baladron V, Ballesta JP, Becam AM, Beinhauer J, Boskovic J, Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Del Rey F, Doignon F, Domdey H, Dubois E, Fiedler T, Fleig U, Floeth M, Fritz C, Gaillardin C, Garcia-Cantalejo JM, Glansdorff NN, Goffeau A, Gueldener U, Herbert C, Heumann K, Heuss-Neitzel D, Hilbert H, Hinni K, Iraqui Houssaini I, Jacquet M, Jimenez A, Jonniaux JL, Karpfinger L, Lanfranchi G, Lepingle A, Levesque H, Lyck R, Maftahi M, Mallet L, Maurer KC, Messenguy F, Mewes HW, Mosti D, Nasr F, Nicaud JM, Niedenthal RK, Pandolfo D, Pierard A, Piravandi E, Planta RJ, Pohl TM, Purnelle B, Rebischung C, Remacha M, Revuelta JL, Rinke M, Saiz JE, Sartorello F, Scherens B, Sen-Gupta M, Soler-Mira A, Urbanus JH, Valle G, Van Dyck L, Verhasselt P, Vierendeels F, Vissers S, Voet M, Volckaert G, Wach A, Wambutt R, Wedler H, Zollner A, Hani J: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Nature. 1997 May 29;387(6632 Suppl):93-8. [PubMed:9169873 ]
  5. O'Reilly MK, Zhang G, Imperiali B: In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry. 2006 Aug 8;45(31):9593-603. doi: 10.1021/bi060878o. [PubMed:16878994 ]
  6. Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [PubMed:24374639 ]
  7. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS: Global analysis of protein expression in yeast. Nature. 2003 Oct 16;425(6959):737-41. doi: 10.1038/nature02046. [PubMed:14562106 ]
  8. Gao XD, Nishikawa A, Dean N: Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. Glycobiology. 2004 Jun;14(6):559-70. doi: 10.1093/glycob/cwh072. Epub 2004 Mar 24. [PubMed:15044395 ]
  9. Absmanner B, Schmeiser V, Kampf M, Lehle L: Biochemical characterization, membrane association and identification of amino acids essential for the function of Alg11 from Saccharomyces cerevisiae, an alpha1,2-mannosyltransferase catalysing two sequential glycosylation steps in the formation of the lipid-linked core oligosaccharide. Biochem J. 2010 Feb 9;426(2):205-17. doi: 10.1042/BJ20091121. [PubMed:19929855 ]