| Identification |
|---|
| HMDB Protein ID
| HMDBP12742 |
| Secondary Accession Numbers
| None |
| Name
| Flavin-dependent halogenase armH1 |
| Synonyms
|
Not Available
|
| Gene Name
| ARMH1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols. The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product. The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Molecular Function |
| monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 57878.735 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| G3FLZ7 |
| UniProtKB/Swiss-Prot Entry Name
| ARMH1_ARMME |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bohnert M, Miethbauer S, Dahse HM, Ziemen J, Nett M, Hoffmeister D: In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2003-6. doi: 10.1016/j.bmcl.2011.02.026. Epub 2011 Feb 12. [PubMed:21376582 ]
- Chi CW, Chen CC, Chen YJ: Therapeutic and radiosensitizing effects of armillaridin on human esophageal cancer cells. Evid Based Complement Alternat Med. 2013;2013:459271. doi: 10.1155/2013/459271. Epub 2013 Jun 24. [PubMed:23864890 ]
- Li Z, Wang Y, Jiang B, Li W, Zheng L, Yang X, Bao Y, Sun L, Huang Y, Li Y: Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J Ethnopharmacol. 2016 May 26;184:119-27. doi: 10.1016/j.jep.2016.02.044. Epub 2016 Mar 4. [PubMed:26952552 ]
- Chang WH, Huang HL, Huang WP, Chen CC, Chen YJ: Armillaridin induces autophagy-associated cell death in human chronic myelogenous leukemia K562 cells. Tumour Biol. 2016 Oct;37(10):14291-14300. doi: 10.1007/s13277-016-5208-6. Epub 2016 Sep 3. [PubMed:27592257 ]
- Sipos G, Anderson JB, Nagy LG: Armillaria. Curr Biol. 2018 Apr 2;28(7):R297-R298. doi: 10.1016/j.cub.2018.01.026. [PubMed:29614282 ]
- Leu YS, Chen YJ, Chen CC, Huang HL: Induction of Autophagic Death of Human Hepatocellular Carcinoma Cells by Armillaridin from Armillaria mellea. Am J Chin Med. 2019;47(6):1365-1380. doi: 10.1142/S0192415X19500708. Epub 2019 Sep 5. [PubMed:31488037 ]
- Liu TP, Chen CC, Shiao PY, Shieh HR, Chen YY, Chen YJ: Armillaridin, a Honey Medicinal Mushroom, Armillaria mellea (Higher Basidiomycetes) Component, Inhibits Differentiation and Activation of Human Macrophages. Int J Med Mushrooms. 2015;17(2):161-8. doi: 10.1615/intjmedmushrooms.v17.i2.70. [PubMed:25746621 ]
- Cromey MG, Drakulic J, Beal EJ, Waghorn IAG, Perry JN, Clover GRG: Susceptibility of Garden Trees and Shrubs to Armillaria Root Rot. Plant Dis. 2020 Feb;104(2):483-492. doi: 10.1094/PDIS-06-19-1147-RE. Epub 2019 Nov 20. [PubMed:31746694 ]
- Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D: A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins. Appl Environ Microbiol. 2015 Dec 11;82(4):1196-1204. doi: 10.1128/AEM.03168-15. Print 2016 Feb 15. [PubMed:26655762 ]
- Misiek M, Braesel J, Hoffmeister D: Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus Armillaria. Fungal Biol. 2011 Aug;115(8):775-81. doi: 10.1016/j.funbio.2011.06.002. Epub 2011 Jun 30. [PubMed:21802058 ]
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