| Identification |
|---|
| HMDB Protein ID
| HMDBP12697 |
| Secondary Accession Numbers
| None |
| Name
| Diguanylate cyclase DgcP |
| Synonyms
|
Not Available
|
| Gene Name
| DGCP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (PubMed:25809128). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (PubMed:25118352). Localizes at the cell poles through interaction with FimV where it increases the local pools of c-di-GMP (By similarity). |
| Pathways
|
- 3',5'-cyclic di-GMP biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell adhesion involved in single-species biofilm formation |
| negative regulation of bacterial-type flagellum-dependent cell motility |
| Cellular Component |
| plasma membrane |
| Molecular Function |
| metal ion binding |
| GTP binding |
| diguanylate cyclase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 671 |
| Molecular Weight
| 73998.11 |
| Theoretical pI
| 4.993 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9HT84 |
| UniProtKB/Swiss-Prot Entry Name
| DGCP_PSEAE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079. [PubMed:10984043 ]
- Nicastro GG, Kaihami GH, Pereira TO, Meireles DA, Groleau MC, Deziel E, Baldini RL: Cyclic-di-GMP levels affect Pseudomonas aeruginosa fitness in the presence of imipenem. Environ Microbiol. 2014 May;16(5):1321-33. [PubMed:25118352 ]
- Aragon IM, Perez-Mendoza D, Moscoso JA, Faure E, Guery B, Gallegos MT, Filloux A, Ramos C: Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections. Environ Microbiol. 2015 Nov;17(11):4332-51. doi: 10.1111/1462-2920.12856. Epub 2015 Apr 28. [PubMed:25809128 ]
|
