| Identification |
|---|
| HMDB Protein ID
| HMDBP12689 |
| Secondary Accession Numbers
| None |
| Name
| Factor V activator RVV-V gamma |
| Synonyms
|
- Russel's viper venom FV activator gamma
- Snake venom serine protease
- RVV-V gamma
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 28823.105 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P18965 |
| UniProtKB/Swiss-Prot Entry Name
| VSPG_DABSI |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sukkapan P, Jia Y, Nuchprayoon I, Perez JC: Phylogenetic analysis of serine proteases from Russell's viper (Daboia russelli siamensis) and Agkistrodon piscivorus leucostoma venom. Toxicon. 2011 Aug;58(2):168-78. doi: 10.1016/j.toxicon.2011.05.014. Epub 2011 May 27. [PubMed:21640745 ]
- Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W: The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences. J Biol Chem. 1988 Nov 25;263(33):17471-81. [PubMed:3053712 ]
- Nakayama D, Ben Ammar Y, Takeda S: Crystallization and preliminary X-ray crystallographic analysis of blood coagulation factor V-activating proteinase (RVV-V) from Russell's viper venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1306-8. doi: 10.1107/S1744309109046697. Epub 2009 Nov 27. [PubMed:20054136 ]
|
