| Identification |
|---|
| HMDB Protein ID
| HMDBP12688 |
| Secondary Accession Numbers
| None |
| Name
| Factor V activator |
| Synonyms
|
- FVA
- VLFVA
- Lebetina viper venom FV activator
- Snake venom serine protease
- LVV-V
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Venom serine protease that converts factor V (F5) to the active form Va in the presence of calcium ions and phospholipids. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Has hydrolytic activities against BAEE (1.2 U/mg), TAME, and Pro-Phe-Arg-MCA (4.9 U/mg). Shows coagulant activity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 28594.75 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9PT41 |
| UniProtKB/Swiss-Prot Entry Name
| VSPF5_MACLB |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Siigur E, Aaspollu A, Siigur J: Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme. Biochem Biophys Res Commun. 1999 Aug 27;262(2):328-32. doi: 10.1006/bbrc.1999.1200. [PubMed:10462474 ]
- Siigur E, Samel M, Tonismagi K, Subbi J, Reintamm T, Siigur J: Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochim Biophys Acta. 1998 Dec 8;1429(1):239-48. doi: 10.1016/s0167-4838(98)00232-5. [PubMed:9920400 ]
- Segers K, Rosing J, Nicolaes GA: Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina. Proteins. 2006 Sep 1;64(4):968-84. doi: 10.1002/prot.21051. [PubMed:16807918 ]
- Siigur J, Aaspollu A, Tonismagi K, Trummal K, Samel M, Vija H, Subbi J, Siigur E: Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis. 2001 May-Dec;31(3-6):123-32. doi: 10.1159/000048055. [PubMed:11910177 ]
|
