| Identification |
|---|
| HMDB Protein ID
| HMDBP12669 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-methylacyl-CoA racemase |
| Synonyms
|
- 2-arylpropionyl-CoA epimerase
- 2-methylacyl-CoA racemase
|
| Gene Name
| AMACR |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:8020470, PubMed:9106621). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:8020470, PubMed:9106621). |
| Pathways
|
- bile acid biosynthesis
- fatty acid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| bile acid biosynthetic process |
| fatty acid metabolic process |
| bile acid metabolic process |
| Cellular Component |
| cytoplasm |
| mitochondrion |
| peroxisome |
| Molecular Function |
| alpha-methylacyl-CoA racemase activity |
| CoA-transferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 41827.705 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P70473 |
| UniProtKB/Swiss-Prot Entry Name
| AMACR_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Schmitz W, Albers C, Fingerhut R, Conzelmann E: Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. Eur J Biochem. 1995 Aug 1;231(3):815-22. [PubMed:7649182 ]
- Ferdinandusse S, Denis S, IJlst L, Dacremont G, Waterham HR, Wanders RJ: Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. J Lipid Res. 2000 Nov;41(11):1890-6. [PubMed:11060359 ]
- Reichel C, Brugger R, Bang H, Geisslinger G, Brune K: Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen. Mol Pharmacol. 1997 Apr;51(4):576-82. doi: 10.1124/mol.51.4.576. [PubMed:9106621 ]
- Schmitz W, Helander HM, Hiltunen JK, Conzelmann E: Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. Biochem J. 1997 Sep 15;326 ( Pt 3):883-9. doi: 10.1042/bj3260883. [PubMed:9307041 ]
- Kotti TJ, Savolainen K, Helander HM, Yagi A, Novikov DK, Kalkkinen N, Conzelmann E, Hiltunen JK, Schmitz W: In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes. J Biol Chem. 2000 Jul 7;275(27):20887-95. doi: 10.1074/jbc.M002067200. [PubMed:10770938 ]
- Reichel C, Bang H, Brune K, Geisslinger G, Menzel S: 2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization. Biochem Pharmacol. 1995 Nov 27;50(11):1803-6. doi: 10.1016/0006-2952(95)02054-3. [PubMed:8615858 ]
|
