| Identification |
|---|
| HMDB Protein ID
| HMDBP12666 |
| Secondary Accession Numbers
| None |
| Name
| Conjugated bile acid hydrolase |
| Synonyms
|
- Bile salt hydrolase
- Chenodeoxycholoyltaurine hydrolase
- Choloylglycine hydrolase
- BSH
|
| Gene Name
| BSH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| bile acid biosynthetic process |
| Cellular Component |
| cell wall |
| Molecular Function |
| chenodeoxycholoyltaurine hydrolase activity |
| choloylglycine hydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 35154.92 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9KK62 |
| UniProtKB/Swiss-Prot Entry Name
| CBH_BIFLN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tanaka H, Hashiba H, Kok J, Mierau I: Bile salt hydrolase of Bifidobacterium longum-biochemical and genetic characterization. Appl Environ Microbiol. 2000 Jun;66(6):2502-12. doi: 10.1128/AEM.66.6.2502-2512.2000. [PubMed:10831430 ]
- Kumar RS, Brannigan JA, Prabhune AA, Pundle AV, Dodson GG, Dodson EJ, Suresh CG: Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase. J Biol Chem. 2006 Oct 27;281(43):32516-25. doi: 10.1074/jbc.M604172200. Epub 2006 Aug 11. [PubMed:16905539 ]
|
