| Identification |
|---|
| HMDB Protein ID
| HMDBP12665 |
| Secondary Accession Numbers
| None |
| Name
| Conjugated bile acid hydrolase |
| Synonyms
|
- CBAH
- Bile salt hydrolase
- CBAH-1
- Choloylglycine hydrolase
- BSH
|
| Gene Name
| CBH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in major human bile salts, such as glycocholate (GCA), taurocholate (TCA) and taurodeoxycholate (TDCA) (PubMed:7618863, PubMed:15823032). Shows a slight preference for taurine-conjugated bile acids as substrates (PubMed:7618863). |
| Pathways
|
- bile acid biosynthesis
- Secondary bile acid biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| bile acid biosynthetic process |
| Molecular Function |
| chenodeoxycholoyltaurine hydrolase activity |
| choloylglycine hydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 329 |
| Molecular Weight
| 37185.0 |
| Theoretical pI
| 5.422 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P54965 |
| UniProtKB/Swiss-Prot Entry Name
| CBH_CLOPE |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [PubMed:11792842 ]
- Coleman JP, Hudson LL: Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl Environ Microbiol. 1995 Jul;61(7):2514-20. [PubMed:7618863 ]
- Rossocha M, Schultz-Heienbrok R, von Moeller H, Coleman JP, Saenger W: Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry. 2005 Apr 19;44(15):5739-48. [PubMed:15823032 ]
|
