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Showing Protein Covalently-linked cell wall protein 14 (HMDBP12649)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12649
Secondary Accession Numbers None
Name Covalently-linked cell wall protein 14
Synonyms Not Available
Gene Name SSR1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Beta-glucan associated cell wall protein involved in cell wall structure. May serve as cross-linking or coat-forming wall protein.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cellular response to drug
fungal-type cell wall organization
Cellular Component
anchored to membrane
plasma membrane
cell surface
extracellular region
fungal-type cell wall
yeast-form cell wall
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 234
Molecular Weight 22550.025
Theoretical pI 4.675
Pfam Domain Function
Signals
  • 1-22;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5AFN8
UniProtKB/Swiss-Prot Entry Name CCW14_CANAL
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
  2. van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
  3. Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
  4. Garcera A, Martinez AI, Castillo L, Elorza MV, Sentandreu R, Valentin E: Identification and study of a Candida albicans protein homologous to Saccharomyces cerevisiae Ssr1p, an internal cell-wall protein. Microbiology (Reading). 2003 Aug;149(Pt 8):2137-2145. doi: 10.1099/mic.0.26301-0. [PubMed:12904553 ]
  5. Lee SA, Wormsley S, Kamoun S, Lee AF, Joiner K, Wong B: An analysis of the Candida albicans genome database for soluble secreted proteins using computer-based prediction algorithms. Yeast. 2003 May;20(7):595-610. doi: 10.1002/yea.988. [PubMed:12734798 ]
  6. De Groot PW, Hellingwerf KJ, Klis FM: Genome-wide identification of fungal GPI proteins. Yeast. 2003 Jul 15;20(9):781-96. doi: 10.1002/yea.1007. [PubMed:12845604 ]
  7. de Groot PW, de Boer AD, Cunningham J, Dekker HL, de Jong L, Hellingwerf KJ, de Koster C, Klis FM: Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins. Eukaryot Cell. 2004 Aug;3(4):955-65. doi: 10.1128/EC.3.4.955-965.2004. [PubMed:15302828 ]
  8. Garcera A, Castillo L, Martinez AI, Elorza MV, Valentin E, Sentandreu R: Anchorage of Candida albicans Ssr1 to the cell wall, and transcript profiling of the null mutant. Res Microbiol. 2005 Nov;156(9):911-20. doi: 10.1016/j.resmic.2005.05.002. Epub 2005 Jun 22. [PubMed:16024227 ]
  9. Plaine A, Walker L, Da Costa G, Mora-Montes HM, McKinnon A, Gow NA, Gaillardin C, Munro CA, Richard ML: Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity. Fungal Genet Biol. 2008 Oct;45(10):1404-14. doi: 10.1016/j.fgb.2008.08.003. Epub 2008 Aug 15. [PubMed:18765290 ]
  10. Sosinska GJ, de Groot PWJ, Teixeira de Mattos MJ, Dekker HL, de Koster CG, Hellingwerf KJ, Klis FM: Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology (Reading). 2008 Feb;154(Pt 2):510-520. doi: 10.1099/mic.0.2007/012617-0. [PubMed:18227255 ]
  11. Castillo L, Calvo E, Martinez AI, Ruiz-Herrera J, Valentin E, Lopez JA, Sentandreu R: A study of the Candida albicans cell wall proteome. Proteomics. 2008 Sep;8(18):3871-81. doi: 10.1002/pmic.200800110. [PubMed:18712765 ]
  12. Sorgo AG, Heilmann CJ, Dekker HL, Bekker M, Brul S, de Koster CG, de Koning LJ, Klis FM: Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell. 2011 Aug;10(8):1071-81. doi: 10.1128/EC.05011-11. Epub 2011 May 27. [PubMed:21622905 ]
  13. Heilmann CJ, Sorgo AG, Siliakus AR, Dekker HL, Brul S, de Koster CG, de Koning LJ, Klis FM: Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile. Microbiology (Reading). 2011 Aug;157(Pt 8):2297-2307. doi: 10.1099/mic.0.049395-0. Epub 2011 May 20. [PubMed:21602216 ]