| Identification |
|---|
| HMDB Protein ID
| HMDBP12643 |
| Secondary Accession Numbers
| None |
| Name
| Tryptophan-rich sensory protein |
| Synonyms
|
- TSPO
- Translocator protein TspO
- TspO regulatory protein
|
| Gene Name
| TSPO |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May play a role in the transmembrane transport of tetrapyrroles and similar compounds, and thereby contribute to the regulation of tetrapyrrole biosynthesis (PubMed:10409680). Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX (PubMed:23651039). Binds protoporphyrin IX, hemin, and coproporphyrin III, but does not bind delta-aminolevulinic acid (PubMed:23952237, PubMed:20541505, PubMed:25635101). Can bind bilirubin, curcumin, gossypol, retinoic acid, cholesterol and the benzodiazepine receptor agonist PK-11195 (in vitro) (PubMed:23952237, PubMed:25635101). Plays a role in the response to low oxygen levels and in the regulation of the biosynthesis of photosynthetic pigments (PubMed:7673149, PubMed:10409680, PubMed:10681549). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| tetrapyrrole metabolic process |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| identical protein binding |
| lipid binding |
| tetrapyrrole binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 17975.995 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 5-25;44-65;73-93;97-119;124-144;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9RFC8 |
| UniProtKB/Swiss-Prot Entry Name
| TSPO_RHOSH |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Choudhary M, Kaplan S: DNA sequence analysis of the photosynthesis region of Rhodobacter sphaeroides 2.4.1. Nucleic Acids Res. 2000 Feb 15;28(4):862-7. doi: 10.1093/nar/28.4.862. [PubMed:10648776 ]
- Yeliseev AA, Kaplan S: A sensory transducer homologous to the mammalian peripheral-type benzodiazepine receptor regulates photosynthetic membrane complex formation in Rhodobacter sphaeroides 2.4.1. J Biol Chem. 1995 Sep 8;270(36):21167-75. doi: 10.1074/jbc.270.36.21167. [PubMed:7673149 ]
- Yeliseev AA, Kaplan S: A novel mechanism for the regulation of photosynthesis gene expression by the TspO outer membrane protein of Rhodobacter sphaeroides 2.4.1. J Biol Chem. 1999 Jul 23;274(30):21234-43. doi: 10.1074/jbc.274.30.21234. [PubMed:10409680 ]
- Yeliseev AA, Kaplan S: TspO of rhodobacter sphaeroides. A structural and functional model for the mammalian peripheral benzodiazepine receptor. J Biol Chem. 2000 Feb 25;275(8):5657-67. doi: 10.1074/jbc.275.8.5657. [PubMed:10681549 ]
- Ginter C, Kiburu I, Boudker O: Chemical catalysis by the translocator protein (18 kDa). Biochemistry. 2013 May 28;52(21):3609-11. doi: 10.1021/bi400364z. Epub 2013 May 13. [PubMed:23651039 ]
- Korkhov VM, Sachse C, Short JM, Tate CG: Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Structure. 2010 Jun 9;18(6):677-87. doi: 10.1016/j.str.2010.03.001. [PubMed:20541505 ]
- Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S: Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science. 2015 Jan 30;347(6221):555-8. doi: 10.1126/science.1260590. [PubMed:25635101 ]
|
