| Identification |
|---|
| HMDB Protein ID
| HMDBP12642 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit delta |
| Synonyms
|
- GABA(A) receptor subunit delta
|
| Gene Name
| GABRD |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| Pathways
|
- GABAergic synapse
- Morphine addiction
- Neuroactive ligand-receptor interaction
- Nicotine addiction
- Retrograde endocannabinoid signaling
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| nervous system process |
| chloride transmembrane transport |
| synaptic transmission |
| signal transduction |
| ion transmembrane transport |
| regulation of membrane potential |
| Cellular Component |
| integral to plasma membrane |
| integral component of postsynaptic membrane |
| GABA-ergic synapse |
| GABA-A receptor complex |
| glutamatergic synapse |
| chloride channel complex |
| synapse |
| neuron projection |
| neuronal cell body |
| dendrite |
| axon |
| Molecular Function |
| chloride channel activity |
| GABA-A receptor activity |
| neurotransmitter receptor activity |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 449 |
| Molecular Weight
| 50521.68 |
| Theoretical pI
| 7.85 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 249-271;275-297;309-331;427-449;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P22933 |
| UniProtKB/Swiss-Prot Entry Name
| GBRD_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sommer B, Poustka A, Spurr NK, Seeburg PH: The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1. DNA Cell Biol. 1990 Oct;9(8):561-8. doi: 10.1089/dna.1990.9.561. [PubMed:2176788 ]
- Wang JB, Kofuji P, Burt DR: Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor. Brain Res Bull. 1992 Jul;29(1):119-23. doi: 10.1016/0361-9230(92)90015-p. [PubMed:1324097 ]
|
