Hmdb loader
Identification
HMDB Protein ID HMDBP12620
Secondary Accession Numbers None
Name Apelin receptor
Synonyms
  1. Angiotensin receptor-like 1
  2. G-protein coupled receptor APJ
  3. MSR
Gene Name APLNR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28854362, PubMed:28890073, PubMed:28663440). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:28371822).
Pathways
  • Apelin signaling pathway
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of cAMP-mediated signaling
venous blood vessel development
vasculature development
vascular associated smooth muscle cell differentiation
regulation of gap junction assembly
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of inhibitory G protein-coupled receptor phosphorylation
endocardial cushion formation
atrioventricular valve development
aorta development
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
coronary vasculature development
apelin receptor signaling pathway
heart looping
vasculogenesis
negative regulation of gene expression
positive regulation of histone deacetylation
G-protein coupled receptor signaling pathway
ventricular septum morphogenesis
regulation of body fluid levels
blood vessel development
gastrulation
adult heart development
positive regulation of angiogenesis
regulation of gene expression
angiogenesis
heart development
Cellular Component
plasma membrane
membrane
integral to membrane
Molecular Function
apelin receptor activity
G protein-coupled receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 377
Molecular Weight 42265.51
Theoretical pI 7.49
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 25-49;65-89;99-123;143-164;199-219;243-269;283-306;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9WV08
UniProtKB/Swiss-Prot Entry Name APJ_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713. doi: 10.1126/science.aam6607. Epub 2017 Jun 29. [PubMed:28663440 ]
  4. Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y: Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203. doi: 10.1016/s0925-4773(99)00081-7. [PubMed:10473142 ]
  5. Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK: Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130. doi: 10.1016/j.celrep.2017.08.014. [PubMed:28854362 ]
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