Hmdb loader
Identification
HMDB Protein ID HMDBP12612
Secondary Accession Numbers None
Name Sensor histidine kinase LiaS
Synonyms Not Available
Gene Name LIAS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation.
Pathways
  • Two-component system
Reactions Not Available
GO Classification
Cellular Component
integral to membrane
plasma membrane
Molecular Function
ATP binding
protein dimerization activity
phosphorelay sensor kinase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 360
Molecular Weight 40703.965
Theoretical pI 7.574
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 16-36;48-68;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O32198
UniProtKB/Swiss-Prot Entry Name LIAS_BACSU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Wipat A, Brignell SC, Guy BJ, Rose M, Emmerson PT, Harwood CR: The yvsA-yvqA (293 degrees-289 degrees) region of the Bacillus subtilis chromosome containing genes involved in metal ion uptake and a putative sigma factor. Microbiology (Reading). 1998 Jun;144 ( Pt 6):1593-1600. doi: 10.1099/00221287-144-6-1593. [PubMed:9639930 ]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. doi: 10.1038/36786. [PubMed:9384377 ]
  3. Kobayashi K, Ogura M, Yamaguchi H, Yoshida K, Ogasawara N, Tanaka T, Fujita Y: Comprehensive DNA microarray analysis of Bacillus subtilis two-component regulatory systems. J Bacteriol. 2001 Dec;183(24):7365-70. doi: 10.1128/JB.183.24.7365-7370.2001. [PubMed:11717295 ]
  4. Mascher T, Margulis NG, Wang T, Ye RW, Helmann JD: Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon. Mol Microbiol. 2003 Dec;50(5):1591-604. doi: 10.1046/j.1365-2958.2003.03786.x. [PubMed:14651641 ]
  5. Mascher T, Zimmer SL, Smith TA, Helmann JD: Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis. Antimicrob Agents Chemother. 2004 Aug;48(8):2888-96. doi: 10.1128/AAC.48.8.2888-2896.2004. [PubMed:15273097 ]
  6. Hyyrylainen HL, Sarvas M, Kontinen VP: Transcriptome analysis of the secretion stress response of Bacillus subtilis. Appl Microbiol Biotechnol. 2005 May;67(3):389-96. doi: 10.1007/s00253-005-1898-1. Epub 2005 Jan 27. [PubMed:15856219 ]
  7. Pietiainen M, Gardemeister M, Mecklin M, Leskela S, Sarvas M, Kontinen VP: Cationic antimicrobial peptides elicit a complex stress response in Bacillus subtilis that involves ECF-type sigma factors and two-component signal transduction systems. Microbiology (Reading). 2005 May;151(Pt 5):1577-1592. doi: 10.1099/mic.0.27761-0. [PubMed:15870467 ]