Hmdb loader
Identification
HMDB Protein ID HMDBP12593
Secondary Accession Numbers None
Name Renin-2
Synonyms
  1. Angiotensinogenase
  2. Submandibular gland renin
Gene Name REN2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood.
Pathways
  • Diabetic cardiomyopathy
  • Renin secretion
  • Renin-angiotensin system
Reactions Not Available
GO Classification
Biological Process
positive regulation of blood pressure
angiotensin maturation
Cellular Component
extracellular space
Molecular Function
endopeptidase activity
aspartic-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 424
Molecular Weight 44282.29
Theoretical pI 6.787
Pfam Domain Function
Signals
  • 1-25;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P00796
UniProtKB/Swiss-Prot Entry Name RENI2_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al.: X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins. Nature. 1992 Jun 11;357(6378):466-72. [PubMed:1608447 ]
  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  4. Misono KS, Chang JJ, Inagami T: Amino acid sequence of mouse submaxillary gland renin. Proc Natl Acad Sci U S A. 1982 Aug;79(16):4858-62. doi: 10.1073/pnas.79.16.4858. [PubMed:6812055 ]
  5. Panthier JJ, Foote S, Chambraud B, Strosberg AD, Corvol P, Rougeon F: Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor. Nature. 1982 Jul 1;298(5869):90-2. doi: 10.1038/298090a0. [PubMed:6283373 ]
  6. Panthier JJ, Dreyfus M, Roux TL, Rougeon F: Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5489-93. doi: 10.1073/pnas.81.17.5489. [PubMed:6089205 ]
  7. Field LJ, Philbrick WM, Howles PN, Dickinson DP, McGowan RA, Gross KW: Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions. Mol Cell Biol. 1984 Nov;4(11):2321-31. doi: 10.1128/mcb.4.11.2321-2331.1984. [PubMed:6392850 ]
  8. Panthier JJ, Rougeon F: Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice. EMBO J. 1983;2(5):675-8. [PubMed:6357783 ]