| Identification |
|---|
| HMDB Protein ID
| HMDBP12436 |
| Secondary Accession Numbers
| None |
| Name
| Potassium channel toxin kappa-KTx 5.1 |
| Synonyms
|
- HelaTx1
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Weak blocker of potassium channels Kv1.1/KCNA1 (IC(50)=9.9 uM) and Kv1.6/KCNA6 (~60% block at 30 uM of toxin) (PubMed:22305749). Acts by binding to the pore and occluding it (PubMed:22305749). Has a voltage-dependent mode of action, which can be explained by a high content of basic residues causing repulsions at higher membrane voltages (PubMed:22305749). Shows a weak interaction with muscle-type nicotinic acetylcholine receptors (nAChR), since it inhibits alpha-bungarotoxin binding to muscle-type nAChR from T.californica (IC(50)=1.4 uM) (PubMed:31276191). This suggests it probably weakly inhibits muscle nAChR (PubMed:31276191). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| host cell postsynaptic membrane |
| Molecular Function |
| toxin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 8379.705 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DJ41 |
| UniProtKB/Swiss-Prot Entry Name
| KKX51_HETLA |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J: Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new kappa-KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24. [PubMed:22305749 ]
- Kasheverov IE, Oparin PB, Zhmak MN, Egorova NS, Ivanov IA, Gigolaev AM, Nekrasova OV, Serebryakova MV, Kudryavtsev DS, Prokopev NA, Hoang AN, Tsetlin VI, Vassilevski AA, Utkin YN: Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18. [PubMed:31276191 ]
|
