| Identification |
|---|
| HMDB Protein ID
| HMDBP12413 |
| Secondary Accession Numbers
| None |
| Name
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
| Synonyms
|
- 2'-phospho-ADP-ribosyl cyclase
- 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
- 2'-phospho-cyclic-ADP-ribose transferase
- ADP-ribosyl cyclase
- NAD glycohydrolase
- NAD(+) nucleosidase
- ADPRC
- ADRC
- NADase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| single fertilization |
| Cellular Component |
| cytoplasmic vesicle |
| Molecular Function |
| transferase activity |
| NAD(P)+ nucleosidase activity |
| NAD+ nucleotidase, cyclic ADP-ribose generating |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 31898.415 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P29241 |
| UniProtKB/Swiss-Prot Entry Name
| NADA_APLCA |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - States DJ, Walseth TF, Lee HC: Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. Trends Biochem Sci. 1992 Dec;17(12):495. [PubMed:1471258 ]
- Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H: CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15;362(Pt 1):125-30. doi: 10.1042/0264-6021:3620125. [PubMed:11829748 ]
- Glick DL, Hellmich MR, Beushausen S, Tempst P, Bayley H, Strumwasser F: Primary structure of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul. 1991 Mar;2(3):211-8. doi: 10.1091/mbc.2.3.211. [PubMed:1650255 ]
- Cakir-Kiefer C, Muller-Steffner H, Schuber F: Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases. Biochem J. 2000 Jul 1;349(Pt 1):203-10. doi: 10.1042/0264-6021:3490203. [PubMed:10861229 ]
- Hellmich MR, Strumwasser F: Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul. 1991 Mar;2(3):193-202. doi: 10.1091/mbc.2.3.193. [PubMed:1650254 ]
- Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD: Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38. Nat Struct Biol. 1996 Nov;3(11):957-64. doi: 10.1038/nsb1196-957. [PubMed:8901875 ]
|
