Hmdb loader
Identification
HMDB Protein ID HMDBP12405
Secondary Accession Numbers None
Name ADP-ribose glycohydrolase MACROD2
Synonyms
  1. MACRO domain-containing protein 2
  2. O-acetyl-ADP-ribose deacetylase MACROD2
  3. [Protein ADP-ribosylaspartate] hydrolase MACROD2
  4. [Protein ADP-ribosylglutamate] hydrolase MACROD2
Gene Name MACROD2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
protein de-ADP-ribosylation
response to DNA damage stimulus
purine nucleoside metabolic process
peptidyl-glutamate ADP-deribosylation
Cellular Component
nucleus
nucleolus
nucleoplasm
Molecular Function
deacetylase activity
hydrolase activity, acting on glycosyl bonds
ADP-ribosylglutamate hydrolase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 425
Molecular Weight 47420.93
Theoretical pI 4.671
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A1Z1Q3
UniProtKB/Swiss-Prot Entry Name MACD2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X: Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Proteomics. 2008 Jul;8(14):2885-96. doi: 10.1002/pmic.200700887. [PubMed:18655026 ]
  5. Rosenthal F, Feijs KL, Frugier E, Bonalli M, Forst AH, Imhof R, Winkler HC, Fischer D, Caflisch A, Hassa PO, Luscher B, Hottiger MO: Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nat Struct Mol Biol. 2013 Apr;20(4):502-7. doi: 10.1038/nsmb.2521. Epub 2013 Mar 10. [PubMed:23474714 ]
  6. Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG: A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol. 2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar 10. [PubMed:23474712 ]
  7. Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I: Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem. 2011 Apr 15;286(15):13261-71. doi: 10.1074/jbc.M110.206771. Epub 2011 Jan 21. [PubMed:21257746 ]