| Identification |
|---|
| HMDB Protein ID
| HMDBP12399 |
| Secondary Accession Numbers
| None |
| Name
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| Synonyms
|
- 2'-phospho-ADP-ribosyl cyclase
- 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
- 2'-phospho-cyclic-ADP-ribose transferase
- ADP-ribosyl cyclase 1
- CD38H
- Cyclic ADP-ribose hydrolase 1
- ADPRC 1
- cADPr hydrolase 1
|
| Gene Name
| CD38 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation. |
| Pathways
|
- Calcium signaling pathway
- Hematopoietic cell lineage
- Nicotinate and nicotinamide metabolism
- Oxytocin signaling pathway
- Pancreatic secretion
- Salivary secretion
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of transcription, DNA-dependent |
| artery smooth muscle contraction |
| response to hormone stimulus |
| negative regulation of neuron projection development |
| response to progesterone stimulus |
| response to interleukin-1 |
| response to hydroperoxide |
| positive regulation of vasoconstriction |
| negative regulation of bone resorption |
| female pregnancy |
| elevation of cytosolic calcium ion concentration |
| B cell receptor signaling pathway |
| negative regulation of apoptotic process |
| negative regulation of transcription, DNA-dependent |
| response to estradiol stimulus |
| response to hypoxia |
| positive regulation of insulin secretion |
| response to drug |
| long term synaptic depression |
| positive regulation of cell proliferation |
| response to retinoic acid |
| positive regulation of cell growth |
| response to cytokine stimulus |
| positive regulation of B cell proliferation |
| Cellular Component |
| basolateral plasma membrane |
| plasma membrane |
| nucleus |
| intracellular membrane-bounded organelle |
| membrane |
| cell surface |
| integral to membrane |
| secretory granule membrane |
| Molecular Function |
| identical protein binding |
| hydrolase activity, acting on glycosyl bonds |
| phosphorus-oxygen lyase activity |
| NAD+ nucleosidase activity |
| NAD(P)+ nucleosidase activity |
| NAD+ nucleotidase, cyclic ADP-ribose generating |
| transferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 303 |
| Molecular Weight
| 34435.6 |
| Theoretical pI
| 8.495 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q64244 |
| UniProtKB/Swiss-Prot Entry Name
| CD38_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Li Q, Yamada Y, Yasuda K, Ihara Y, Okamoto Y, Kaisaki PJ, Watanabe R, Ikeda H, Tsuda K, Seino Y: A cloned rat CD38-homologous protein and its expression in pancreatic islets. Biochem Biophys Res Commun. 1994 Jul 15;202(1):629-36. doi: 10.1006/bbrc.1994.1974. [PubMed:8037769 ]
- Koguma T, Takasawa S, Tohgo A, Karasawa T, Furuya Y, Yonekura H, Okamoto H: Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans. Biochim Biophys Acta. 1994 Aug 11;1223(1):160-2. doi: 10.1016/0167-4889(94)90087-6. [PubMed:8061050 ]
- Sun L, Adebanjo OA, Moonga BS, Corisdeo S, Anandatheerthavarada HK, Biswas G, Arakawa T, Hakeda Y, Koval A, Sodam B, Bevis PJ, Moser AJ, Lai FA, Epstein S, Troen BR, Kumegawa M, Zaidi M: CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. J Cell Biol. 1999 Sep 6;146(5):1161-72. doi: 10.1083/jcb.146.5.1161. [PubMed:10477767 ]
- Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H: CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15;362(Pt 1):125-30. doi: 10.1042/0264-6021:3620125. [PubMed:11829748 ]
|
