| Identification |
|---|
| HMDB Protein ID
| HMDBP12398 |
| Secondary Accession Numbers
| None |
| Name
| Outer membrane channel protein CpnT |
| Synonyms
|
Not Available
|
| Gene Name
| CPNT |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| The N-terminal domain (NTD) forms an outer membrane channel and is used for uptake of nutrients across the outer membrane. Also confers susceptibility to structurally different antibiotics and antituberculosis drugs, and to toxic immune factors such as nitric oxide (NO). The C-terminal domain (TNT) is dispensable for normal growth in macrophages. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| ion transport |
| Cellular Component |
| cell surface |
| extracellular region |
| cell outer membrane |
| pore complex |
| Molecular Function |
| NAD glycohydrolase activity |
| porin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 846 |
| Molecular Weight
| 88333.865 |
| Theoretical pI
| 5.494 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A0H3MAA9 |
| UniProtKB/Swiss-Prot Entry Name
| CPNT_MYCBP |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, Dos Santos S, Duthoy S, Lacroix C, Garcia-Pelayo C, Inwald JK, Golby P, Garcia JN, Hewinson RG, Behr MA, Quail MA, Churcher C, Barrell BG, Parkhill J, Cole ST: Genome plasticity of BCG and impact on vaccine efficacy. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5596-601. doi: 10.1073/pnas.0700869104. Epub 2007 Mar 19. [PubMed:17372194 ]
- Danilchanka O, Pires D, Anes E, Niederweis M: The Mycobacterium tuberculosis outer membrane channel protein CpnT confers susceptibility to toxic molecules. Antimicrob Agents Chemother. 2015 Apr;59(4):2328-36. doi: 10.1128/AAC.04222-14. Epub 2015 Feb 2. [PubMed:25645841 ]
|
