| Identification |
|---|
| HMDB Protein ID
| HMDBP12363 |
| Secondary Accession Numbers
| None |
| Name
| Choline O-acetyltransferase |
| Synonyms
|
- CHOACTase
- ChAT
- Choline acetylase
|
| Gene Name
| CHAT |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. |
| Pathways
|
- Cholinergic synapse
- Glycerophospholipid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| neurotransmitter biosynthetic process |
| Molecular Function |
| choline O-acetyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 641 |
| Molecular Weight
| 71729.95 |
| Theoretical pI
| 7.524 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P13222 |
| UniProtKB/Swiss-Prot Entry Name
| CLAT_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Berrard S, Brice A, Lottspeich F, Braun A, Barde YA, Mallet J: cDNA cloning and complete sequence of porcine choline acetyltransferase: in vitro translation of the corresponding RNA yields an active protein. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9280-4. doi: 10.1073/pnas.84.24.9280. [PubMed:3480542 ]
- Berrard S, Brice A, Mallet J: Molecular genetic approach to the study of mammalian choline acetyltransferase. Brain Res Bull. 1989 Jan;22(1):147-53. doi: 10.1016/0361-9230(89)90139-1. [PubMed:2713713 ]
- Hersh LB, Kong CF, Sampson C, Mues G, Li YP, Fisher A, Hilt D, Baetge EE: Comparison of the promoter region of the human and porcine choline acetyltransferase genes: localization of an important enhancer region. J Neurochem. 1993 Jul;61(1):306-14. doi: 10.1111/j.1471-4159.1993.tb03569.x. [PubMed:8515278 ]
- Braun A, Barde YA, Lottspeich F, Mewes W, Thoenen H: N-terminal sequence of pig brain choline acetyltransferase purified by a rapid procedure. J Neurochem. 1987 Jan;48(1):16-21. doi: 10.1111/j.1471-4159.1987.tb13121.x. [PubMed:3794697 ]
|
