| Identification |
|---|
| HMDB Protein ID
| HMDBP12362 |
| Secondary Accession Numbers
| None |
| Name
| Microbial anti-inflammatory molecule |
| Synonyms
|
- MAM
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Plays an anti-inflammatory role in the mammalian intestine. The supernatant of this bacteria, or 2 purified fractions containing peptides derived from this protein, exerts inhibitory effects on IL1-beta-induced IL-8 secretion in intestinal epithelial CaCO-2 cells (PubMed:18936492, PubMed:26045134). Mice fed this bacterium suffer less severe symptoms in 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced colitis (PubMed:18936492). Expression in human epithelial cell lines (HEK293T, HT29) shows a decrease in activation of NF-kappa-B induced by Carma-1 (CARD11) or lipopolysaccharide. The decrease occurs in a MAM-dose dependent manner. Also inhibits activation induced by IKBKB in HEK293T cells. Expression in cell lines has no effect on the STAT3 pathway. L.lactis expressing the protein offers a protective effect to mice in dinitrobenzene sulfonic acid (DNBS) and dextran sodium sulfate (DSS)-induced colitis (PubMed:26045134, PubMed:28203226). It may play a role in maintaining the intestinal barrier, which is important in diabetes mellitus (Probable). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 14500.51 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| C7H4X2 |
| UniProtKB/Swiss-Prot Entry Name
| MAM_FAEPA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Quevrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermudez-Humaran LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P: Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut. 2016 Mar;65(3):415-425. doi: 10.1136/gutjnl-2014-307649. Epub 2015 Jun 4. [PubMed:26045134 ]
- Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottiere HM, Dore J, Marteau P, Seksik P, Langella P: Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6. doi: 10.1073/pnas.0804812105. Epub 2008 Oct 20. [PubMed:18936492 ]
- Breyner NM, Michon C, de Sousa CS, Vilas Boas PB, Chain F, Azevedo VA, Langella P, Chatel JM: Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-kappaB Pathway. Front Microbiol. 2017 Feb 1;8:114. doi: 10.3389/fmicb.2017.00114. eCollection 2017. [PubMed:28203226 ]
- Xu J, Liang R, Zhang W, Tian K, Li J, Chen X, Yu T, Chen Q: Faecalibacterium prausnitzii-derived microbial anti-inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression. J Diabetes. 2020 Mar;12(3):224-236. doi: 10.1111/1753-0407.12986. Epub 2019 Oct 30. [PubMed:31503404 ]
|
