| Identification |
|---|
| HMDB Protein ID
| HMDBP12359 |
| Secondary Accession Numbers
| None |
| Name
| Pullulanase A |
| Synonyms
|
- Alpha-dextrin endo-1,6-alpha-glucosidase
- Pullulan 6-glucanohydrolase
|
| Gene Name
| SPUA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells. Hydrolyzes the alpha-1,6-branchpoints of glycogen (By similarity). Hydrolyzes pullulan (PubMed:11083842). Does not hydrolyze dextran. Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific carbohydrate-binding protein, which binds to amylose (pure alpha-(1,4)-linked glucose), amylopectin (alpha-(1,4)-linked glucose with alpha-(1,6) branch points), pullulan (linear polymer of mixed alpha-(1,4)- and alpha-(1,6)-linked glucose) and glycogen (similar to amylopectin with more frequent alpha-(1,6) branch points) in vitro. Does not bind to dextran (a linear polymer of alpha-(1,6)-linked glucose) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| pathogenesis |
| Cellular Component |
| cell surface |
| extracellular region |
| cell wall |
| Molecular Function |
| metal ion binding |
| carbohydrate binding |
| pullulanase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 143315.98 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9F930 |
| UniProtKB/Swiss-Prot Entry Name
| PULA_STREE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bongaerts RJ, Heinz HP, Hadding U, Zysk G: Antigenicity, expression, and molecular characterization of surface-located pullulanase of Streptococcus pneumoniae. Infect Immun. 2000 Dec;68(12):7141-3. doi: 10.1128/IAI.68.12.7141-7143.2000. [PubMed:11083842 ]
|
