| Identification |
|---|
| HMDB Protein ID
| HMDBP12347 |
| Secondary Accession Numbers
| None |
| Name
| Subtilisin-like serine protease Pen c 1 |
| Synonyms
|
- Alkaline serine protease
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Serine protease (PubMed:10103041, PubMed:7763554). Hydrolyzes azocasein (PubMed:10103041). Cleaves peptide bonds of the oxidized insulin B chain preferably at 15-Leu-|-Tyr-16, but also at 4-Gln-|-His-5 and 24-Phe-|-Phe-25, and to a lesser extent at 5-His-|-Leu-6 and 25-Phe-|-Tyr-26. Hydrolyzes amide bonds between amino acids and 7-amino-4-methylcoumarin (AMC) in vitro (PubMed:7763554). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| proteolysis |
| Cellular Component |
| extracellular space |
| Molecular Function |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 40383.44 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Y749 |
| UniProtKB/Swiss-Prot Entry Name
| PENC1_PENCI |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Su NY, Yu CJ, Shen HD, Pan FM, Chow LP: Pen c 1, a novel enzymic allergen protein from Penicillium citrinum. Purification, characterization, cloning and expression. Eur J Biochem. 1999 Apr;261(1):115-23. doi: 10.1046/j.1432-1327.1999.00242.x. [PubMed:10103041 ]
- Yamamoto N, Matsumoto K, Yamagata Y, Hirano K, Ichishima E: A heat-labile serine proteinase from Penicillium citrinum. Phytochemistry. 1993 Apr;32(6):1393-7. doi: 10.1016/0031-9422(93)85144-g. [PubMed:7763554 ]
- Chow LP, Su NY, Yu CJ, Chiang BL, Shen HD: Identification and expression of Pen c 2, a novel allergen from Penicillium citrinum. Biochem J. 1999 Jul 1;341 ( Pt 1):51-9. [PubMed:10377244 ]
- Shen HD, Lin WL, Liaw SF, Tam MF, Han SH: Characterization of the 33-kilodalton major allergen of Penicillium citrinum by using MoAbs and N-terminal amino acid sequencing. Clin Exp Allergy. 1997 Jan;27(1):79-86. [PubMed:9117886 ]
|
