| Identification |
|---|
| HMDB Protein ID
| HMDBP12339 |
| Secondary Accession Numbers
| None |
| Name
| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| Synonyms
|
- MTA/SAH nucleosidase
- MTAN
- 5'-deoxyadenosine nucleosidase
- 5'-methylthioadenosine nucleosidase
- S-adenosylhomocysteine nucleosidase
- DOA nucleosidase
- dAdo nucleosidase
- MTA nucleosidase
- AdoHcy nucleosidase
- SAH nucleosidase
- SRH nucleosidase
|
| Gene Name
| MTNN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. |
| Pathways
|
- Biosynthesis of amino acids
- Cysteine and methionine metabolism
- L-methionine biosynthesis via salvage pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| L-methionine salvage from methylthioadenosine |
| L-methionine salvage from S-adenosylmethionine |
| purine deoxyribonucleoside catabolic process |
| Molecular Function |
| adenosylhomocysteine nucleosidase activity |
| methylthioadenosine nucleosidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 232 |
| Molecular Weight
| 24353.725 |
| Theoretical pI
| 5.246 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A1A7K5 |
| UniProtKB/Swiss-Prot Entry Name
| MTNN_ECOK1 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]
|
