| Identification |
|---|
| HMDB Protein ID
| HMDBP12338 |
| Secondary Accession Numbers
| None |
| Name
| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| Synonyms
|
- MTA/SAH nucleosidase
- MTAN
- 5'-deoxyadenosine nucleosidase
- 5'-methylthioadenosine nucleosidase
- S-adenosylhomocysteine nucleosidase
- DOA nucleosidase
- dAdo nucleosidase
- MTA nucleosidase
- AdoHcy nucleosidase
- SAH nucleosidase
- SRH nucleosidase
|
| Gene Name
| MTNN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. |
| Pathways
|
- Biosynthesis of amino acids
- Cysteine and methionine metabolism
- L-methionine biosynthesis via salvage pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| L-methionine salvage from methylthioadenosine |
| L-methionine salvage from S-adenosylmethionine |
| nucleoside catabolic process |
| Molecular Function |
| adenosylhomocysteine nucleosidase activity |
| methylthioadenosine nucleosidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 228 |
| Molecular Weight
| 24753.285 |
| Theoretical pI
| 5.301 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q4L6V0 |
| UniProtKB/Swiss-Prot Entry Name
| MTNN_STAHJ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K: Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol. 2005 Nov;187(21):7292-308. doi: 10.1128/JB.187.21.7292-7308.2005. [PubMed:16237012 ]
|
