| Identification |
|---|
| HMDB Protein ID
| HMDBP12337 |
| Secondary Accession Numbers
| None |
| Name
| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| Synonyms
|
- MTA/SAH nucleosidase
- MTAN
- 5'-deoxyadenosine nucleosidase
- 5'-methylthioadenosine nucleosidase
- S-adenosylhomocysteine nucleosidase
- DOA nucleosidase
- dAdo nucleosidase
- MTA nucleosidase
- AdoHcy nucleosidase
- SAH nucleosidase
- SRH nucleosidase
|
| Gene Name
| MTNN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. |
| Pathways
|
- Biosynthesis of amino acids
- Cysteine and methionine metabolism
- L-methionine biosynthesis via salvage pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| L-methionine salvage from methylthioadenosine |
| L-methionine salvage from S-adenosylmethionine |
| purine deoxyribonucleoside catabolic process |
| Molecular Function |
| adenosylhomocysteine nucleosidase activity |
| methylthioadenosine nucleosidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 232 |
| Molecular Weight
| 24373.725 |
| Theoretical pI
| 5.39 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q5PD46 |
| UniProtKB/Swiss-Prot Entry Name
| MTNN_SALPA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - McClelland M, Sanderson KE, Clifton SW, Latreille P, Porwollik S, Sabo A, Meyer R, Bieri T, Ozersky P, McLellan M, Harkins CR, Wang C, Nguyen C, Berghoff A, Elliott G, Kohlberg S, Strong C, Du F, Carter J, Kremizki C, Layman D, Leonard S, Sun H, Fulton L, Nash W, Miner T, Minx P, Delehaunty K, Fronick C, Magrini V, Nhan M, Warren W, Florea L, Spieth J, Wilson RK: Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid. Nat Genet. 2004 Dec;36(12):1268-74. doi: 10.1038/ng1470. Epub 2004 Nov 7. [PubMed:15531882 ]
|
