| Identification |
|---|
| HMDB Protein ID
| HMDBP12333 |
| Secondary Accession Numbers
| None |
| Name
| Probable tRNA sulfurtransferase |
| Synonyms
|
- Sulfur carrier protein ThiS sulfurtransferase
- Thiamine biosynthesis protein ThiI
- tRNA 4-thiouridine synthase
|
| Gene Name
| THII |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. |
| Pathways
|
- Biosynthesis of cofactors
- Sulfur relay system
- thiamine diphosphate biosynthesis
- Thiamine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| tRNA thio-modification |
| thiamine diphosphate biosynthetic process |
| thiamine biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| ATP binding |
| tRNA binding |
| tRNA adenylyltransferase activity |
| sulfurtransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 402 |
| Molecular Weight
| 44730.225 |
| Theoretical pI
| 6.966 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| B9E7C5 |
| UniProtKB/Swiss-Prot Entry Name
| THII_MACCJ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Baba T, Kuwahara-Arai K, Uchiyama I, Takeuchi F, Ito T, Hiramatsu K: Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci. J Bacteriol. 2009 Feb;191(4):1180-90. doi: 10.1128/JB.01058-08. Epub 2008 Dec 12. [PubMed:19074389 ]
|
