| Identification |
|---|
| HMDB Protein ID
| HMDBP12317 |
| Secondary Accession Numbers
| None |
| Name
| ABC multidrug transporter MDR2 |
| Synonyms
|
- Multidrug resistance protein 2
|
| Gene Name
| MDR2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). May play a role in pathogenicity (PubMed:19141731). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| ATP binding |
| ATPase-coupled transmembrane transporter activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 145278.17 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 93-113;147-167;219-239;242-262;325-345;358-378;762-782;810-830;884-904;910-930;995-1015;1025-1045;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A059JJ46 |
| UniProtKB/Swiss-Prot Entry Name
| MDR2_TRIIM |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Persinoti GF, Martinez DA, Li W, Dogen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioglu-Polat S, Ilkit M, Graser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA: Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21. [PubMed:29467168 ]
- Martins MP, Franceschini ACC, Jacob TR, Rossi A, Martinez-Rossi NM: Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes. J Med Microbiol. 2016 Jul;65(7):605-610. doi: 10.1099/jmm.0.000268. Epub 2016 Apr 26. [PubMed:27121717 ]
- Fachin AL, Ferreira-Nozawa MS, Maccheroni W, Martinez-Rossi NM: Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. J Med Microbiol. 2006 Aug;55(Pt 8):1093-1099. doi: 10.1099/jmm.0.46522-0. [PubMed:16849730 ]
- Paiao FG, Segato F, Cursino-Santos JR, Peres NT, Martinez-Rossi NM: Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs. FEMS Microbiol Lett. 2007 Jun;271(2):180-6. doi: 10.1111/j.1574-6968.2007.00710.x. Epub 2007 Apr 10. [PubMed:17425668 ]
- Maranhao FCA, Paiao FG, Fachin AL, Martinez-Rossi NM: Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. J Med Microbiol. 2009 Feb;58(Pt 2):163-168. doi: 10.1099/jmm.0.002907-0. [PubMed:19141731 ]
|
