| Identification |
|---|
| HMDB Protein ID
| HMDBP12179 |
| Secondary Accession Numbers
| None |
| Name
| Farnesyl pyrophosphate synthase |
| Synonyms
|
- FPP synthase
- FPS
- (2E,6E)-farnesyl diphosphate synthase
- Dimethylallyltranstransferase
- Farnesyl diphosphate synthase
- Geranyltranstransferase
|
| Gene Name
| FDPS |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). |
| Pathways
|
- farnesyl diphosphate biosynthesis
- geranyl diphosphate biosynthesis
- Human T-cell leukemia virus 1 infection
- Influenza A
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral reproduction |
| cholesterol biosynthetic process |
| farnesyl diphosphate biosynthetic process |
| geranyl diphosphate biosynthetic process |
| Cellular Component |
| cytoplasmic vesicle |
| Molecular Function |
| metal ion binding |
| dimethylallyltranstransferase activity |
| geranyltranstransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 40509.97 |
| Theoretical pI
| 5.173 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8WMY2 |
| UniProtKB/Swiss-Prot Entry Name
| FPPS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Lefebvre L, Vanderplasschen A, Ciminale V, Heremans H, Dangoisse O, Jauniaux JC, Toussaint JF, Zelnik V, Burny A, Kettmann R, Willems L: Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. J Virol. 2002 Feb;76(3):1400-14. [PubMed:11773414 ]
|
