| Identification |
|---|
| HMDB Protein ID
| HMDBP12165 |
| Secondary Accession Numbers
| None |
| Name
| ABC multidrug transporter MDR1 |
| Synonyms
|
- Multidrug resistance protein 1
|
| Gene Name
| MDR1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including ethidium bromide, ketoconazole, cycloheximide, fluconazole, griseofulvin, imazalil and itraconazole. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| ATP binding |
| ATPase-coupled transmembrane transporter activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 174820.68 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 543-563;571-591;636-656;661-681;691-711;798-818;1231-1251;1257-1277;1305-1325;1345-1365;1372-1392;1498-1518;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A059J0G5 |
| UniProtKB/Swiss-Prot Entry Name
| MDR1_TRIIM |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Persinoti GF, Martinez DA, Li W, Dogen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioglu-Polat S, Ilkit M, Graser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA: Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21. [PubMed:29467168 ]
- Cervelatti EP, Fachin AL, Ferreira-Nozawa MS, Martinez-Rossi NM: Molecular cloning and characterization of a novel ABC transporter gene in the human pathogen Trichophyton rubrum. Med Mycol. 2006 Mar;44(2):141-7. doi: 10.1080/13693780500220449. [PubMed:16519017 ]
- Martins MP, Franceschini ACC, Jacob TR, Rossi A, Martinez-Rossi NM: Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes. J Med Microbiol. 2016 Jul;65(7):605-610. doi: 10.1099/jmm.0.000268. Epub 2016 Apr 26. [PubMed:27121717 ]
|
