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Showing Protein Developmental and secondary metabolism regulator veA (HMDBP12161)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP12161
Secondary Accession Numbers None
Name Developmental and secondary metabolism regulator veA
Synonyms
  1. Velvet complex subunit A
Gene Name VEA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity). Controls the expression of hundreds of genes, including those comprising more than a dozen known secondary metabolite gene clusters (PubMed:24116213). Controls the expression of the gliotoxin gene cluster (PubMed:23087369). Controls the expression of the fumagillin, fumitremorgin G, fumigaclavine C and glionitrin gene clusters (PubMed:24116213). The regulation of the fumagillin gene cluster and fumagillin production is performed through direct control of the expression of fumR (PubMed:24116213). Negatively regulates conidiation (PubMed:22970834, PubMed:23087369). Required for normal protease activity (PubMed:23087369).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
asexual sporulation resulting in formation of a cellular spore
conidiophore development
negative regulation of conidiophore development
negative regulation of sexual sporulation resulting in formation of a cellular spore
positive regulation of asexual sporulation resulting in formation of a cellular spore
positive regulation of gliotoxin biosynthetic process
spore germination
Cellular Component
cytoplasm
nucleus
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 570
Molecular Weight 63031.625
Theoretical pI 9.314
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID E9RCK4
UniProtKB/Swiss-Prot Entry Name VEA_ASPFU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. doi: 10.1038/nature04332. [PubMed:16372009 ]
  2. Dhingra S, Lind AL, Lin HC, Tang Y, Rokas A, Calvo AM: The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. PLoS One. 2013 Oct 7;8(10):e77147. doi: 10.1371/journal.pone.0077147. eCollection 2013. [PubMed:24116213 ]
  3. Pain A, Woodward J, Quail MA, Anderson MJ, Clark R, Collins M, Fosker N, Fraser A, Harris D, Larke N, Murphy L, Humphray S, O'Neil S, Pertea M, Price C, Rabbinowitsch E, Rajandream MA, Salzberg S, Saunders D, Seeger K, Sharp S, Warren T, Denning DW, Barrell B, Hall N: Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb region encompassing the nitrate assimilation gene cluster. Fungal Genet Biol. 2004 Apr;41(4):443-53. doi: 10.1016/j.fgb.2003.12.003. [PubMed:14998527 ]
  4. Krappmann S, Bayram O, Braus GH: Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module. Eukaryot Cell. 2005 Jul;4(7):1298-307. doi: 10.1128/EC.4.7.1298-1307.2005. [PubMed:16002655 ]
  5. Dhingra S, Andes D, Calvo AM: VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus. Eukaryot Cell. 2012 Dec;11(12):1531-43. doi: 10.1128/EC.00222-12. Epub 2012 Oct 19. [PubMed:23087369 ]
  6. Park HS, Bayram O, Braus GH, Kim SC, Yu JH: Characterization of the velvet regulators in Aspergillus fumigatus. Mol Microbiol. 2012 Nov;86(4):937-53. doi: 10.1111/mmi.12032. Epub 2012 Sep 25. [PubMed:22970834 ]