Hmdb loader
Identification
HMDB Protein ID HMDBP12158
Secondary Accession Numbers None
Name C6 finger transcription factor fumR
Synonyms
  1. Fumagillin gene cluster regulator
Gene Name FUMR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of pseurotin and fumagillin (PubMed:24116213).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
fumagillin biosynthetic process
positive regulation of fumagillin biosynthetic process
positive regulation of pseurotin A biosynthetic process
pseurotin A biosynthetic process
Cellular Component
nucleus
Molecular Function
zinc ion binding
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 622
Molecular Weight 68144.705
Theoretical pI 8.208
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q4WAY8
UniProtKB/Swiss-Prot Entry Name FUMR_ASPFU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Molina JM, Tourneur M, Sarfati C, Chevret S, de Gouvello A, Gobert JG, Balkan S, Derouin F: Fumagillin treatment of intestinal microsporidiosis. N Engl J Med. 2002 Jun 20;346(25):1963-9. [PubMed:12075057 ]
  2. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. doi: 10.1038/nature04332. [PubMed:16372009 ]
  3. KILLOUGH JH, MAGILL GB, SMITH RC: The treatment of amebiasis with fumagillin. Science. 1952 Jan 18;115(2977):71-2. doi: 10.1126/science.115.2977.71. [PubMed:14913169 ]
  4. Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM: The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103. doi: 10.1073/pnas.94.12.6099. [PubMed:9177176 ]
  5. Lazarus DD, Doyle EG, Bernier SG, Rogers AB, Labenski MT, Wakefield JD, Karp RM, Clark EJ, Lorusso J, Hoyt JG, Thompson CD, Hannig G, Westlin WF: An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis. Inflamm Res. 2008 Jan;57(1):18-27. doi: 10.1007/s00011-007-7075-5. [PubMed:18209961 ]
  6. Dhingra S, Lind AL, Lin HC, Tang Y, Rokas A, Calvo AM: The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. PLoS One. 2013 Oct 7;8(10):e77147. doi: 10.1371/journal.pone.0077147. eCollection 2013. [PubMed:24116213 ]
  7. Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang CC, Keller NP: Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17065-70. doi: 10.1073/pnas.1313258110. Epub 2013 Sep 30. [PubMed:24082142 ]