| Identification |
|---|
| HMDB Protein ID
| HMDBP12151 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme elegaxobin-1 |
| Synonyms
|
- SVTLE
- Elegaxobin I
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like snake venom serine protease that clots rabbit fibrinogen. Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B. Incubation with human fibrinogen alpha and beta resulted in cleavage of both fibrinogen chains but generated neither fibrinopeptide A nor fibrinopeptide B. Promotes clotting of rabbit fibrinogen, but not bovine or human fibrinogen. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| envenomation resulting in fibrinogenolysis in other organism |
| envenomation resulting in negative regulation of blood coagulation in other organism |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 25439.76 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P84788 |
| UniProtKB/Swiss-Prot Entry Name
| VSP1_PROEL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Oyama E, Takahashi H: Amino acid sequence of a thrombin like enzyme, elegaxobin, from the venom of Trimeresurus elegans (Sakishima-habu). Toxicon. 2002 Jul;40(7):959-70. doi: 10.1016/s0041-0101(02)00092-2. [PubMed:12076650 ]
- Oyama E, Takahashi H: Purification and characterization of a thrombin-like enzyme, elegaxobin, from the venom of Trimeresurus elegans (Sakishima-habu). Toxicon. 2000 Aug;38(8):1087-100. doi: 10.1016/s0041-0101(99)00220-2. [PubMed:10708800 ]
|
