| Identification |
|---|
| HMDB Protein ID
| HMDBP12150 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme elegaxobin-2 |
| Synonyms
|
- SVTLE
- Elegaxobin II
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like snake venom serine protease that clots rabbit fibrinogen. Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B. Human and bovine fibrinogen are unaffected. Also cleaves Met-Lys and Arg-Ser bonds in heat-denatured bovine plasma kininogen to release Lys-bradykinin. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of blood pressure |
| envenomation resulting in fibrinogenolysis in other organism |
| envenomation resulting in negative regulation of blood coagulation in other organism |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 25590.79 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P84787 |
| UniProtKB/Swiss-Prot Entry Name
| VSP2_PROEL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Oyama E, Takahashi H: Amino acid sequence of a thrombin like enzyme, elegaxobin II, from the venom of Trimeresurus elegans (Sakishima-Habu). Toxicon. 2004 Dec 1;44(7):711-21. doi: 10.1016/j.toxicon.2004.07.007. [PubMed:15500847 ]
- Oyama E, Takahashi H: Purification and characterization of a thrombin like enzyme, elegaxobin II, with lys-bradykinin releasing activity from the venom of Trimeresurus elegans (Sakishima-Habu). Toxicon. 2003 Apr;41(5):559-68. doi: 10.1016/s0041-0101(02)00363-x. [PubMed:12676434 ]
|
